grate
chap someone's hide
get up someone's nose
get under someone's skin
tickle the dragon's tail
give someone ass cancer
naggle
nerve-racking
get under one's goat
importune
cut up nasty
cut up rough
grind one's gears
cringeful
annoyance
irritatable
provoke
mither
neg
cop the needle
wake up on the wrong side of bed
nerve-rackingly
comb someone's hair the wrong way
rub someone the wrong way
lose one's temper
grig
irritable
raise someone's hackles
get someone's back up
boil someone's piss
rub up the wrong way
arc up
discomfort
grind
test someone's patience
get someone's Irish up
piggle
send shivers down someone's spine
irritation
get someone's dander up
heated
prickly
get up someone's ass
drive someone crazy
argh
nark
set someone's teeth on edge
get on someone's tits
get someone's goat
spleen