upend
get to
break up
discomfort
make the feathers fly
shake up
trying
stick in someone's craw
fuck with
hit one hard
confronting
decatenate
grieve
set someone's teeth on edge
upset
rock
weigh on
get up someone's ass
anguish
offend
comb someone's hair the wrong way
pain
hurt
arc up
disconcert
blow a gasket
importune
get under one's goat
grig
flip out
twist the knife
ruffle some feathers
torque off
boil someone's piss
see red
play the devil with
distressingly
give someone ass cancer
irritate
wind up
rustle someone's jimmies
mither
neg
exacerbatingly
scar
touch
tick off
take on the chin
upsetting
shit-stir
impact
annoy
provoke
too close for comfort
cut up
spleen
drive someone crazy
disturb
nark
drive someone up the wall
get on someone's tits
hot and bothered
rub someone the wrong way
do someone's head in
overset
distressing
get under someone's skin
frustrate
aggravate
ire
upsettingness
butthurt
worry
strike
hit
umbrageous
rile up
sodomise
lose one's temper
tormenting
upsettable
sore
disturbing
stressfully
tough
skeeve
harsh
rankle
frost
irritable
cunt
rame
bearbait
overaggravate
heartwrenching
get one's bowels in an uproar
irritatingly
aggro

English words for 'To affect or upset drastically.'

As you may have noticed, above you will find words for "To affect or upset drastically.". Hover the mouse over the word you'd like to know more about to view its definition. Click search related words by phrase or description. to find a better fitting word. Finally, thanks to ChatGPT, the overall results have been greatly improved.

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