begruntle
come unhinged
unhinge
hobble
bother
kerfuffle
kreistle
shake
neg
annoy
shit-stir
wrack
rub someone the wrong way
set someone's teeth on edge
unseat
get under someone's skin
get under one's goat
inconvenience
send shivers down someone's spine
rustle someone's jimmies
ruffle someone's feathers
appall
discomfort
disconcert
hagride
trouble
give someone ass cancer
bring down
pudder
agitate
jolt
worry
ball-bust
bug
grig
funk
tease
reek
comb someone's hair the wrong way
harrow
knit one's brows
shock
skeeve
break up
oppress
consternate
boil someone's piss
spleen
unsoothe
drive someone crazy