discomfort
botherance
pet hate
pet peeve
disturbance
shuddersome
annoying
ruffle someone's feathers
Job's comforter
inconvenience
get a rise out of
excitation
excitement
frustration
squick
turd in the punchbowl
agitant
annoyance
laugh
thorn
pain in the ass
irritant
bother
inclemency
hobgoblin
bugbear
perplexity
red rag to a bull
put the cat among the pigeons
miff
seeing red
discomfortableness
wag a finger
huff
red rag
pestilential
bitch
shock to the system
tickle the dragon's tail
fly in the ointment
dislike
pain in the butt
Linus blanket
wretchedness
offend
turnover
red flag
displeasure
Jiminy Cricket
overturn
perturb
jeepers creepers
ach
trigger
jar
uncanny
upset
bum
envy
dear God
dismayer
plaguy
irritation
bothering
criminently
ick
curse it
worrying
nettlesome
irritational
give someone the creeps
get up someone's nose
blister
care
disturbing
eat
turn-off
knickers
shake
intimidation
irritate
deterrence
vexation
kreistle
disgust
unhinge
pinprick
unacceptable
creep out
make someone's jaw drop
make someone's teeth itch
determent
feh
consternate
worry someone sick

English words for 'Something that disturbs one’s comfort; an annoyance.'

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