sickness unto death
self-despair
cope
misanthropic
misanthropical
weight of the world
cynical
nonsuffering
smart
plightless
aiyo
desperate
queasiness
slough of despond
nervousness
despairfulness
nerves
surrender
suffering
resignation
distress
despairer
neglected
maladjustment
desperation
hurt
broken bird
compunction
unfortunate
devil-ridden
disheartened
unfortunate person
remorse
self-reproach
self-pity
de profundis
atelophobia
skid row
nostalgic
despairful
pathetic
disease of despair
ridiculous
silly
bad taste in one's mouth
unhope
botheration
annoyance
discontent
infliction
pain
daze
stupor
sadness
shock
bother
pain in the ass
dark
pain in the neck
comparison is the thief of joy
tormented
intolerable
unbearable
unendurable
chagrin
hopelessness
gloomy
pity party
put oneself in someone's place
disappointing
tortured
living death
despairingness
hooped
excess baggage
depression
disillusionary
despair
depressive
emotional cripple
life's a bitch and then you die
peccancy
dismals
starve
pisser
despairing
lonely
wanweird
disconcerted
uncoping
apology
self-pitying
wretchedness
dead man walking

English words for 'Personal despair over the disquieting circumstances of human existence.'

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