unhinged
sick
off one's head
out of one's mind
chemically imbalanced
off-minded
frail
twisted
demented
breakdown
weak-minded
dysfunctionality
flat
screwed up
mentally challenged
deranged
depressive
depressoid
one's elevator doesn't go all the way to the top
in one's head
sicko
basket case
icky
peaked
moody
deficit
indisposed
under the weather
unwell
ailing
low
soft
poopy
poorly
decompensation
seedy
sickly
hypothymergasia
snap
clear-eyed
unsound
infirm
mentally ill
pathological
unstable
enervate
anoia
apprehensive
disturbance
unclouded
upset
perturbation
worried
depressedly
touched in the head
down-crested
gaga
introcession
afflicted
dismals
feeblemindedness
clouded
discomfort
impaired
unmoored
psychotic
hebetude
unhealthy
fragile
down horrendous
insane
disorder
depressing
doited
cafard
bummy
fucked in the head
sick-ass
debility
umbilicate
flop sweat
sap
few cards shy of a full deck
far gone
cut up
psychrophilicity
stressed out
distraction
psychically
nerfed
scrobiculus
melancholy
morbidity
morbidness
uncomfortable
automaniac
break down
malaised
agitated