demented
off-minded
unhinged
chemically imbalanced
pagal
few cards shy of a full deck
sick-ass
psycho
mad person
twisted
unstable
mentally ill
toys in the attic
unsound
one brick short of a full load
dementia
madbrained
mad
disorderer
crack up
psychosyndrome
discomfort
crazy as a pet coon
mad as a hatter
mad as a mongoose
insane
sicko
screw loose
aberration
insaniac
pathological
hugger-mugger
higgledy-piggledy
disorderly
clouded
topsy-turvy
mentally challenged
valetudinarian
jumbled
manicky
-phrenia
sick
brainsick
unbalanced
crazy
disturbed
hypothymergasia
hysterical
wretchedness
icky