wide-reaching
consequential
fargoing
resultful
moment
consequence
import
effecting
causality
seismic
side-effecting
effectful
side effect
fallout
brunt
reverberate
game-changing
impact
significant
adversative
make all the difference
impressed
add up to
curarimimetic
rejuvenation
effected
big deal
great
iatrogenesis
consignificant
ill effect
bite
strike a blow
métier
drastic
clinicosignificance
hit like a ton of bricks
useful
dripping water hollows a stone
red-letter
imponderable
big
beneficious
second-line
Purkinje shift
prohedonic
operative
poisoned
necessarily
between
changeable
redound
impactful
double whammy
difference
measurable
pleiotropy
gift that keeps on giving
draining
repercuss
efficacy
first cause
quantum
exhausting
dunnage
contrahedonic
large
add to
nosocomial
feel
affectedly
bifactor
instrumental
hypersignificant
beneficially
conditioner
higher than a kite
soak up
synergistic
help
inimical
by-product
multifactorially
maleffect
therapeutic
aid
interactive
syllogize
side-effect
acute
semiessential
leaps and bounds
telling
test drive
impressive
essence
intertreatment

English words for 'Having significant and widely applicable effects.'

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