nettle
comb someone's hair the wrong way
tee off
tickle the dragon's tail
get on someone's nerves
neg
get under someone's skin
give someone ass cancer
raise someone's hackles
rub up the wrong way
get someone's back up
irk
gall
get under one's goat
get someone's goat
do someone's head in
drive someone up the wall
boil someone's piss
fret
mither
give someone the shits
ruffle some feathers
raunch out
rustle someone's jimmies
vituperate
provoke
break someone's balls
rub someone the wrong way
worry
torque off
put out
bust someone's balls
pillory
get up someone's ass
shit-stir
get someone's dander up
discomfit
importune
get someone's Irish up
grind one's gears
grig
get at
chafe
give it large
hurt someone's feelings
set someone's teeth on edge
tease
annoy
make a spectacle of oneself
test someone's patience