worm in the apple
perfect storm
kiss of death
cobra effect
loss
backfiring
undo
curate's egg
tar baby
bungholing
badass
doomedness
perdition
catastrophic
harm
wanfortune
disimprovement
goat rope
own goal
foredoom
raddled
spoilt
worse
ruinatious
who shot John
poop on
break
dick up
Pandora's box
scuzz up
wreck
hash
trash fire
a bad penny always turns up
mullock
kick someone when they are down
monovacancy
fault
blessing in disguise
mystifier
misadventure
turd in the punchbowl
bug
crab
mischance
spoiled
puzzler
run into the ground
disimprove
ruinator
teaser
puzzle
mishap
botch up
downfalling
disaster
trainwreck in slow motion
horrendousness
dismalize
catastrophe
troublement
flaw
problematize
the jug goes to the well until it breaks
soup
teeerrible
worsening
you can't polish a turd
unlucky
nefastous
doomward
problem
problemise
have a fable for
spoilsome
come to grief
imperfection
queer up
lousy
jialat
unsolvable
despair
misboding
metaproblem
butchery
crippling
blunderful
dog
blow
reversal
shatterable
black eye
caco-
reverse
setback
muck up